Saffron was born in Vancouver, British Columbia, Canada and is the daughter of Bill Henderson the lead guitarist and singer of the Canadian rock band Chilliwack She is best known for her voice acting roles rather than her live acting roles, specifically Gohan in Dragon Ball Z, RoboCop: Alpha Commando, Double Dragon, and Eri in InuYasha.
She is also a singer. She has one sister Camille Henderson who is also a singer. She is diabetic. She is married and has at least one child.